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Memory B cells in the lung may be important for more effective influenza vaccinations
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Using a mouse model of influenza and experiments that included parabiosis, researchers definitively showed that lung-resident memory B cells establish themselves in the lung soon after influenza infection. Those lung memory B cells responded more quickly to produce antibodies against influenza after a second infection, as compared to the response by the circulating memory B cells in lymphoid tissue, and establishment of the lung-resident memory B cells required a local antigen encounter in the lung.