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Mild blast forces cause brain pathology and deficits, despite lack of macroscopic damage
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Using a rat model of bTBI, researchers show how even mild exposure to a single blast shock wave is able to induce small but potentially very meaningful pathogenic effects that accumulate with time. These effects, detected at the microscopic level, included microvascular damage, injury to nerve axons and signs of neuroinflammation in various brain regions. Brain function also changed, as shown by impaired short-term synaptic plasticity.