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Experts from across Europe have developed a set of competencies in antimicrobial prescribing and stewardship, using a structured consensus procedure. This ESCMID-led study has resulted in a list of competencies that represent the minimum standards that all independent prescribers of antimicrobials should reach to practice according to principles of responsible antibiotic use. The list of competencies is highly relevant for educators, regulators and professional bodies throughout Europe, as well as for individual prescribers.