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Patients with X-linked lymphoproliferative syndrome type 1 (XLP1) are at risk of fatal infectious mononucleosis. Here, a Tokyo Medical and Dental University (TMDU)-led research team performed detailed analyses of T cells in a family with a mild form of XLP1. They found small populations of CD4+ and CD8+ T cells expressing SLAM-associated protein at normal levels, suggesting that less invasive therapies, which affect fewer T cells, may be useful in treatment of XLP1.